Many people are reporting issues with various gamepads/game controllers and Macs. I was able to get a USB gamepad to work on my MacBook Pro (running MacOS Monterey) by installing (from the App store) a tool called Gamepad Mapper. Then I simply mapped the x-axis (which didn’t work at first) to keyboard keys (which my game also supports). I also had to allow this software in the security settings (accessibility submenu).
Now my Retro-bit NES USB controller works just fine with my Construct 3 video game. Check out the game King David RPG here: